Gerald S. Shadel
Salk Institute for Biological Studies
Public scientific profile · Unclaimed
Built from public scholarly sources. Expertise is inferred by ScienceWe from publications and has not been confirmed by the scientist.
Top expertise
Mitochondrial Function and Pathology
Strong evidence · 4 supporting papers · latest 2026
interferon and immune responses
Strong evidence · 3 supporting papers · latest 2026
Drug Transport and Resistance Mechanisms
Strong evidence · 1 supporting paper · latest 2025
Adenosine and Purinergic Signaling
Strong evidence · 1 supporting paper · latest 2025
Epigenetics and DNA Methylation
Strong evidence · 1 supporting paper · latest 2025
Autophagy in Disease and Therapy
Strong evidence · 1 supporting paper · latest 2025
Calcium signaling and nucleotide metabolism
Strong evidence · 1 supporting paper · latest 2025
RNA modifications and cancer
Strong evidence · 1 supporting paper · latest 2025
Publications (15)
Bile acid synthesis impedes tumor-specific T cell responses during liver cancer
2025DOIPMID 39787217
Multi-site phosphorylation of BCL2L13 in a TBK1- and AMPK-dependent manner reveals new modes of mitophagy regulation
2025DOIPMID 40672348
FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion
2024DOIPMID 39868925
ROS-dependent localization of glycolytic enzymes to mitochondria
2025DOIPMID 40803248
Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and metabolic inflexibility
2024DOI
Chronic type II interferon promotes tumor growth through mitochondrial RNA–induced type I interferon and prostaglandin synthesis
2026DOIPMID 42721225
Structural and biological bases of cGAS bending bubble DNA to form a hyperactive dimer 2310028
2026DOI
Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
2026DOIPMID 42696571
cGAS bends unpaired DNA to form an unconventional structure that hyperactivates the innate immune response
2026DOIPMID 42244631
IL-10/ACOD1 axis regulates catabolism of phagocytosed lipids in trained macrophages
2026DOI
Abstract 169: A TNF-producing neutrophil subset drives age-dependent hepatotoxicity.
2026DOI
Abstract 4312 MITOCHONDRIAL COMPLEX II INHIBITION PROMOTES TUMOR INFLAMMATION
2026DOI
Kidney mitochondrial DNA contributes to systemic IL-6 release in sepsis-associated acute kidney injury
2025DOIPMID 41355794
Retraction Notice to “Aberrant CD8+ T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling” [Am J Pathol 178 (2011) 2740–2751]
2025DOIPMID 40998509
Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer
2024DOI
Organizations in sourced records
Affiliation evidence only — not confirmed current employment.
- Salk Institute for Biological Studies
Source: OpenAlex · retrieved 2026-09-29