Michael Downes
Salk Institute for Biological Studies
Public scientific profile · Unclaimed
Built from public scholarly sources. Expertise is inferred by ScienceWe from publications and has not been confirmed by the scientist.
Top expertise
Histone Deacetylase Inhibitors Research
Strong evidence · 3 supporting papers · latest 2026
Pancreatic and Hepatic Oncology Research
Strong evidence · 4 supporting papers · latest 2026
Mitochondrial Function and Pathology
Strong evidence · 1 supporting paper · latest 2026
Adipose Tissue and Metabolism
Strong evidence · 1 supporting paper · latest 2026
Pancreatitis Pathology and Treatment
Solid evidence · 2 supporting papers · latest 2026
Vitamin D Research Studies
Solid evidence · 1 supporting paper · latest 2026
Drug Transport and Resistance Mechanisms
Solid evidence · 1 supporting paper · latest 2026
Protein Degradation and Inhibitors
Solid evidence · 3 supporting papers · latest 2026
Publications (15)
A phase II clinical trial of albumin-bound paclitaxel, cisplatin, gemcitabine (NABPLAGEM), and paricalcitol as neoadjuvant therapy in pancreatic cancer
2026DOIPMID 42268676
HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery
2026DOIPMID 42348617
A scalable embryonic stem cell–based platform for efficient generation of mitochondrial DNA mutant mice
2026DOIPMID 41950089
Limiting De Novo Lipogenesis Unlocks the Thermogenic Potential of Glucose in Brown Fat
2026DOI
Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis
2026DOIPMID 42379165
HDAC Inhibition Sensitizes Pancreatic Tumors to DNA Damage by Global Redistribution of the Transcriptional Machinery
2026DOIPMID 42239268
Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: a randomized, multiarm, run-in phase trial
2026DOIPMID 42185478
CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma
2026DOIPMID 42244695
SMRT regulation of nuclear receptors orchestrates bile acid homeostasis
2026DOIPMID 42717237
Abstract LB097: HDAC inhibition sensitizes pancreatic cancer to DNA-damaging therapies via genome-wide redistribution of transcriptional machinery
2026DOI
CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasation
2026DOIPMID 41993312
Abstract A052: CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated seeding in mice
2026DOI
Abstract A079: Leveraging a human chronic pancreatitis organoid biobank for pancreatic cancer interception
2026DOI
Abstract B101: Stroma-tumor crosstalk converges with oncogenic KRAS signaling to drive an NFκB-mediated immune evasion program
2026DOI
FGF1 orchestrates circadian hepatic triglyceride secretion
2026DOIPMID 41857047
Organizations in sourced records
Affiliation evidence only — not confirmed current employment.
- Salk Institute for Biological Studies
Source: OpenAlex · retrieved 2026-09-29